Supporting[edit][]
- Doctors and medical students
- Stanley Tucci as Dr. Kevin Moretti, Chief of Emergency Medicine
- Leland Orser as Dr. Lucien Dubenko, Chief of Surgery
- Kari Matchett as Dr. Skye Wexler, Acting Chief of Emergency Medicine
- David Lyons as Dr. Simon Brenner, ER Attending Physician
- Sam Anderson as Dr. Jack Kayson, Chief of Cardiology
- Amy Aquino as Dr. Janet Coburn, Chief of Obstetrics
- John Aylward as Dr. Donald Anspaugh, Chief of Staff
- J. P. Manoux as Dr. Dustin Crenshaw, Surgical Attending Physician
- Gina Ravera as Dr. Betina DeJesus, Radiologist
- Busy Philipps as Dr. Hope Bobeck, Intern
- Malaya Rivera Drew as Katey Alvaro, Medical Student
- Charles Esten as Dr. Grossman, Orthopedics
- Robert Gossett as Dr. Everett Daniels, Hospital Board Member
- Anthony Starke as Dr. Craig, Orthopedics
- Michael Buchman Silver as Dr. Paul Meyers, Psychiatrist
- Steven Christopher Parker as Dr. Harold Zalinsky, Surgical Intern
- Gil McKinney as Dr. Paul Grady, ER Intern
- Bresha Webb as Laverne St. John, Medical Student
- Julia Jones as Kaya Montoya, Medical Student
- Marc Jablon as Dr. Larry Weston, Second Year Resident
- Patrick Cassidy as Dr. Ramsey
- Nurses
- Deezer D as Nurse Malik McGrath
- Laura Cerón as Nurse Chuny Marquez
- Yvette Freeman as Nurse Haleh Adams
- Lily Mariye as Nurse Lily Jarvik
- Dinah Lenney as Nurse Shirley
- Angel Laketa Moore as Nurse Dawn Archer
- Bellina Logan as Nurse Kit
- Nadia Shazana as Nurse Jacy
- Nasim Pedrad as Nurse Suri
- Mónica Guzmán as Nurse Marisol
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- Staff, Paramedics and Officers
- Troy Evans as Desk Clerk Frank Martin
- Jesse Borrego as Desk Clerk Javier
- Reiko Aylesworth as Julia Dupree, Hospital Chaplain
- Emily Wagner as Paramedic Doris Pickman
- Montae Russell as Paramedic Dwight Zadro
- Lyn Alicia Henderson as Paramedic Pamela Olbes
- Brian Lester as Paramedic Brian Dumar
- Michelle C. Bonilla as Paramedic Christine Harms
- Demetrius Navarro as Paramedic Morales
- Louie Liberti as Paramedic Bardelli
- Brendan Patrick Connor as Paramedic Reidy
- Meg Thalken as Chopper EMT Dee McManus
- Christopher Amitrano as Officer Hollis
- Demetrius Grosse as Officer Newkirk
- Joe Manganiello as Officer Litchman
- Family
- Chloe Greenfield as Sarah Riley
- Bill Bolender as Hank Riley
- Frances Conroy as Becky Riley
- Sam Jones III as Chaz Pratt, EMT
- Rebecca Hazlewood as Jaspreet
- Michael Rady as Brian Moretti
- Andrew Gonzales and Aidan Gonzales as Joe Kovač
- Zoran Radanovich as Niko Kovač
Guest stars[edit][]
- Gloria Reuben as Jeanie Boulet, Physician Assistant
- Cress Williams as Officer Reggie Moore
- Mae Whitman as Heather
- Peter Fonda as Pierce Tanner
- Jonathan Banks as Dr Robert Truman
- Hal Holbrook as Walter Perkins
- Josh Stewart as Daniel
- Mariana Klaveno as Rebecca
- Steve Buscemi as Art Masterson
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