Supporting cast[edit][]
- Doctors and Medical students
- William H. Macy as Dr. David Morgenstern – Chief of Surgery and Emergency Medicine
- Sam Anderson as Dr. Jack Kayson – Chief of Cardiology
- Amy Aquino as Dr. Janet Coburn – Chief of Obstetrics and Gynecology
- John Aylward as Dr. Donald Anspaugh – Chief of Staff
- CCH Pounder as Dr. Angela Hicks – Surgical Attending Physician
- Glenne Headly as Dr. Abby Keaton – Pediatric Surgeon
- Maria Bello as Dr. Anna Del Amico – Pediatric Emergency Medicine Fellow
- Jorja Fox as Dr. Maggie Doyle – Intern PGY-1
- Omar Epps as Dr. Dennis Gant – Surgical Intern PGY-1
- Matthew Glave as Dr. Dale Edson – Surgical Intern PGY-1
- Iqbal Theba as Dr. Zagerby – Ophthalmologist
- Harry Lennix as Dr. Greg Fischer – From Infectious Diseases department
- Perry Anzilotti as Dr. Ed – Anesthesiologist
- Don Perry as Dr. Sam Breedlove – Surgical Attending Physician
- Ted Rooney as Dr. Tabash – Neonatologist
- Jami Gertz as Dr. Nina Pomerantz – Psychiatrist
- Melissa Chan as Dr. Leung Joo Hua
- Dwier Brown as Dr. David Herlihy
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- Nurses
- Ellen Crawford as Nurse Lydia Wright
- Conni Marie Brazelton as Nurse Conni Oligario
- Deezer D as Nurse Malik McGrath
- Laura Cerón as Nurse Chuny Marquez
- Yvette Freeman as Nurse Haleh Adams
- Lily Mariye as Nurse Lily Jarvik
- Vanessa Marquez as Nurse Wendy Goldman
- Jenny O'Hara as Temp Nurse Rhonda Sterling
- Dinah Lenney as Nurse Shirley
- Bellina Logan as Nurse Kit
- Lucy Rodriguez as Nurse Bjerke
- Suzanne Carney as OR Nurse Janet
- Staff, Paramedics and Officers
- Abraham Benrubi as Desk Clerk Jerry Markovic
- Kristin Minter as Desk Clerk Miranda "Randi" Fronczak
- Charles Noland as Desk Clerk E. Ray "E-Ray" Bozman
- Deborah May as Director of Nursing Mary Cain
- Erica Gimpel as Social Worker Adele Newman
- Skip Stellrecht as Chaplain Miller
- Mike Genovese as Officer Al Grabarsky
- Ron Eldard as Paramedic Ray "Shep" Shepard
- Emily Wagner as Paramedic Doris Pickman
- Montae Russell as Paramedic Dwight Zadro
- Lyn Alicia Henderson as Paramedic Pamela Olbes
- Brian Lester as Paramedic Brian Dumar
- J.P. Hubbell as Paramedic Lars Audia
- Meg Thalken as Chopper EMT Dee McManus
- Family
- Christine Harnos as Jennifer "Jenn" Greene
- Yvonne Zima as Rachel Greene
- Michael Beach as Al Boulet
- Khandi Alexander as Jackie Robbins
- Ving Rhames as Walter Robbins
- Lisa Nicole Carson as Carla Reece
- Rose Gregorio as Helen Hathaway
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