Del Amico first appeared in the show in 1997, guest starring in the last three episodes of the third season. Having previously completed a Pediatrics residency, she comes to County General as an Emergency Medicine Intern who wishing to double-board in both Emergency Medicine and Pediatrics. As a series regular in the fourth season, her experience as a Pediatrician initially causes friction with Doug Ross, who is a Pediatric Emergency Medicine Fellow. She becomes a doctor consultant in the clinic run by Carol Hathaway. She helps John Carter detox his cousin, Chase, as she's experienced in the subject from having to detox someone before with her ex-boyfriend, Max, and knows what he is going through. During her brief stint at County General, Anna also became good friends with Carol and Elizabeth Corday.
Anna starts to become close to Carter through the season, and even admits there has been some chemistry between the two of them, but she never exactly exchanges the same strong feelings Carter has for her. Anna was very insulted when she discovers Carter's family fortune that he kept secret. Anna felt betrayed and fooled after giving him a glimpse of her poor struggling lifestyle. She never felt secure in such a wealthy setting and was always happy with her 'getting by day to day' persona. The two hold the same passion for medicine and eventually share a kiss. Carter and Anna's relationship is strained when Anna's ex Dr. Max Rocher comes to Chicago to see her. Anna isn't too confident in trusting Max after his rough drug addiction, and is frustrated whenever she has to deal with Carter and Max in the same room. Her character is not seen again after the end of Season 4.
She was mentioned again in the fifth season and her disappearance was explained to Lucy Knight, who received her locker after her departure, by Carter. She was said to have moved to Philadelphia to work in a pediatric ER, and that it was better for her because it was where she was from, where she grew up, where her family was, and that she had a boyfriend there.
At the end of the Season 15 episode "The Book of Abby", long-serving nurse Haleh Adams shows the departing Dr. Abby Lockhart a closet wall where all the past doctors and employees have put their locker name tags. Amongst them, the tag "Del Amico" can be seen. The same happens again during "Shifting Equilibrium", when Dr. Neela Rasgotra puts her own name tag on the wall.
|Characters||Mark Greene • Doug Ross • Susan Lewis • John Carter • Carol Hathaway • Peter Benton • Jeanie Boulet • Kerry Weaver • Anna Del Amico • Elizabeth Corday • Lucy Knight • Luka Kovač • Abby Lockhart • Cleo Finch • Dave Malucci • Jing-Mei Chen • Michael Gallant • Greg Pratt • Neela Rasgotra • Samantha Taggart • Ray Barnett • Archie Morris • Tony Gates • Simon Brenner • Cate Banfield|